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SELECTED ABSTRACTS FOR POSTER PRESENTATIONS IN ALPHABETIC ORDER ACCORDING TO THE NAME OF THE FIRST AUTHOR

Abstract # BIOLOGY POSTERS
1 SENSITIVE SCREENING AND MONITORING OF BTK C481S MUTATIONS IN CHRONIC LYMPHOCYTIC LEUKEMIA USING DROPLET DIGITAL PCR
Csaba Bödör, Dóra Aczél, Zoltán Mátrai, László Tamás, Ferenc Takács, Gábor Barna, Richárd Kiss, Gábor Mikala, András Masszi, Péter Farkas, Alexandra Balogh, Sarolta Illés, Judit Demeter, Julia Gaál-Weisinger, Hussain Alizadeh, Béla Kajtár, Róbert Szász, Tímea Gurbity Pálfi, Adrienn Sulák, Balázs Kollár, Miklós Egyed, Márk Plander, László Rejtő, László Szerafin, Dóra Lévai, Tamás Schneider, Donát Alpár, Lili Kotmayer
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2 THE KRAB ZINC-FINGER PROTEIN ZNF224 IS A POTENTIAL PROGNOSTIC MARKER AND THERAPEUTIC TARGET IN CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)
Elena Cesaro, Rosa Catapano, Arianna Pastore, Raffaele Sessa, Marialuigia Iannalfo, Federico Chiurazzi, Michela Grosso, Paola Costanzo
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3 TUMOR MUTATIONAL BURDEN IS ASSOCIATED WITH CYTOGENETIC COMPLEXITY AND DETECTS PATIENTS WITH EVOLVING CHRONIC LYMPHOCYTIC LEUKEMIA: RESULTS OF A BICENTRIC STUDY
Jasmine Chauzeix, Cédric Pastoret, Lucie Donaty, Nathalie Gachard, Thierry Fest, Jean Feuillard, David Rizzo
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4 COMBINED ANALYSIS OF VARIANT ALLELE FREQUENCY AND NORMALIZED READ COUNTS TO DETECT GENOMIC IMBALANCIES IN CLL BY TARGETED HIGH THROUGHPUT SEQUENCING
Jasmine Chauzeix, Paco Derouault, Anne-Sophie Lia, Stéphane Merillou, Lucie Donaty, Marie-Pierre Laforêt, Sylvie Bourthoumieux, Nataliya Dmytruk, Jean Feuillard, Nathalie Gachard, David Rizzo
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5 PERSONALIZED PREDICTION OF DRUG DOSE
Andrea Cremaschi, Henrik Bendiksen, Johanne U. Hermansen, Ludvig A. Munthe, Geir E. Tjønnfjord, Kjetil Taskén, Sigrid S. Skånland
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6 CCR7 IN CLL: KNOCKING ON CLL HEAVEN´S DOORS
Carlos Cuesta-Mateos, Raquel Juarez-Sánchez, Tamara Mateu-Albero, Cecilia Muñoz-Calleja, Fernando Terrón, Wim Mol
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7 QUANTIFICATION OF MINIMAL RESIDUAL DISEASE BY HIGH-THROUGHPUT SEQUENCING OF IGHV GENES IN CLL
Marine Dupont, Alexis Saint-Amand, Paco Derouault, Mélanie Boulin, Nataliya Dmytruk, Jasmine Chauzeix, Jean Feuillard, Nathalie Gachard, David Rizzo
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8 DETECTION OF CLL-TYPE STEREOTYPED BCR BY HIGH THROUGHPUT SEQUENCING IN HEALTHY PEOPLE WITHOUT ANY HEMATOLOGICAL PAST HISTORY
Marine Dupont, Alexis Saint-Amand, Paco Derouault, Mélanie Boulin, Nataliya Dmytruk, Jasmine Chauzeix, Jean Feuillard, Nathalie Gachard, David Rizzo
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9 DECIPHERING CHRONIC LYMPHOCYTIC LEUKEMIA BY NOVEL NANO-FUNCTIONAL PROTEOMICS APPROACHES: NOVEL INSIGHTS FROM THE GLOBAL PHOSPHOPROTEME
Manuel Fuentes
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10 ASSOCIATION OF GENETIC POLYMORPHISMS WITH DIFFERENTIAL CATALASE GENE EXPRESSION IN PROGNOSTIC GROUPS OF CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS
Marilisa Galasso, Chiara Cavallini, Francesca Maria Quaglia, Ilaria Dando, Ornella Lovato, Mauro Krampera, Massimo Donadelli, Maria Grazia Romanelli, Maria Teresa Scupoli
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11 A SMALL MOLECULE INHIBITOR OF ROR1 (KAN0441571C) INDUCED APOPTOSIS OF IBRUTINIB RESISTANT AND DOUBLE-REFRACTORY CLL CELLS
Amineh Ghaderi, Mohammad-Ali Okhovat , Layung Sekar Sih Wikanthi , Ann Svensson , Marzia Palma, Johan Schultz, Thomas Olin, Mohammad Hojjat-Farsangi, Håkan Mellstedt and Anders Österborg
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12 THE BAF CHROMATIN REMODELING COMPLEX IS A NOVEL TARGET OF SPLICEOSOME DEREGULATION IN SF3B1 MUTATED CHRONIC LYMPHOCYTIC LEUKEMIA
Daniel Hägerstrand, Diego Cortese, Ying Qu, Amrei Binzer-Panchal, Aron Skaftason, Viktor Ljungström, Karla Plevova, Evangelia Stalika, Andreas Agathangelidis, Lydia Scarfo, Marine Armand, Alice Muggen, Neil Kay, Tait Shanafelt, Davide Rossi, Sarka Pospisilova, Frederic Davi, Anton Langerak, Paolo Ghia, Kostas Stamatopoulos, Lesley-Ann Sutton, Richard Rosenquist
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13 TWO NOVEL TRNA-DERIVED FRAGMENTS POSSESS CLINICAL UTILITY AS MOLECULAR BIOMARKERS IN CHRONIC LYMPHOCYTIC LEUKEMIA
Paraskevi Karousi, Katerina Katsaraki, Sotirios G. Papageorgiou, Vasiliki Pappa, Diamantis C. Sideris, Andreas Scorilas, Christos K. Kontos
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14 ZEBRAFISH “AVATARS” AS A TOOL FOR PERSONALIZED TREATMENT OF CLL PATIENTS
Ana Logrado, Vanda Póvoa, Filipa Barahona, Joana Caetano, Raquel Lopes, Sonia Leocádio, Manuel Neves, Paulo Lucio, Rita Fior, Cristina João
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15 SHANK1 AS A PREDICTIVE, DIAGNOSTIC AND PROGNOSTIC METHYLATION BIOMARKER AND A POSSIBLE FUNCTIONAL PLAYER IN CHRONIC LYMPHOCYTIC LEUKEMIA
Eleonora Loi, Loredana Moi, Antonio Fadda, Giannina Satta, Mariagrazia Zucca, Sonia Sanna, Shadi Amini Nia, Giuseppina Cabras, Marina Padoan, Corrado Magnani, Lucia Miligi, Sara Piro, Davide Gentilini, Maria Grazia Ennas, Melissa C Southey, Graham G Giles, Nicole Wong Doo, Pierluigi Cocco, Patrizia Zavattari
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16 HISTONE VARIANT MACROH2A1 IS DOWNREGULATED UPON BTK INHIBITION IN CHRONIC LYMPHOCYTIC LEUKAEMIA
Charlotte McDonald, Charalampos Xanthopoulos, Mark Catherwood, Ken Mills and Efterpi Kostareli
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17 IDENTIFICATION OF NEW PUTATIVE DRIVER MUTATIONS AND PREDICTORS OF DISEASE EVOLUTION IN CHRONIC LYMPHOCYTIC LEUKEMIA
Adrián Mosquera Orgueira, Beatriz Antelo Rodriguez, Jose Angel Diaz Arias, Roi Ferreiro Ferro, Paula Melero Valentin, Andrés Peleteiro Raindo, Miguel Cid López and Jose Luis Bello Lopez
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18 LOXO-305: A HIGHLY SELECTIVE AND NON-COVALENT BRUTON’S TYROSINE KINASE INHIBITOR TARGETING IBRUTINIB-RESISTANT CLL
Aishath S Naeem, Winnie I Nguy, Svitlana Teykucheva, Stacey M Fernandes, Vanessa Rai, Kevin Ebata, Eliana B Gomez, Barb J Brandhuber, Stephen M Rothenberg, Jennifer R Brown
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19 OVEREXPRESSION OF WILD-TYPE RRAS2 DRIVES B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA (B-CLL)
Clara L. Oeste, Alejandro M. Hortal, Claudia Cifuentes, Miguel Sánchez Alcoceba, Marcos González Díaz, Balbino Alarcón
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20 OVERCOMING VENETOCLAX RESISTANCE IN CLL BY ANTAGONISM OF STROMAL TGF-Β MEDIATED DRUG RESISTANCE
Eugene Park, Jingyu Chen, Andrew Moore, Maurizio Mangolini, Alexander Egle, Seth Frietze and Ingo Ringshausen
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21 CO-OCCURRENCE OF BIALLELIC ATM AND TP53 ALTERATIONS IS RARELY DETECTED IN CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) AND RESULTS IN DEFECTIVE MITOSIS IN CLL CRISPR/CAS9-GENERATED CELLULAR MODELS
Claudia Pérez-Carretero, Miguel Quijada-Álamo, María Hernández-Sánchez, Ana E Rodríguez-Vicente, Ana Belén Herrero, Jesús-María Hernández-Sánchez, Marta Martín-Izquierdo, Teresa González, Sandra Santos-Minguez, Cristina Miguel-García, Jose-Angel Hernandez-Rivas, Rocío Benito, José-Luis Ordóñez, Jesús María Hernández-Rivas
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22 THE INTERPLAY OF BCR SIGNALLING AND ADHESION CONTROLLED BY LIPID PHOSPHATASES PTEN AND SHIP1
Michael Persicke, Peter Lichter, Stephan Stilgenbauer, Daniel Mertens
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23 MONOCLONAL B CELLS OF CLL PHENOTYPE EXPRESS AN AUTONOMOUSLY SIGNALING B-CELL RECEPTOR
Edwin Quinten, Kees van Bergen, Dietmar Pfeifer, Katja Zirlik, Ruben Groen, Hassan Jumaa, Hendrik Veelken
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24 SINGLE-CELL TRANSCRIPTOMIC ANALYSIS OF RESPONDERS AND NON-RESPONDERS TO COMBINATION IBRUTINIB AND CART CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA
Ruben Raychaudhuri, Maxim Shestov, David Porter, Saar Gill
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25 ENERGY UTILISATION IN CHRONIC LYMPHOCYTIC LEUKAEMIA – COMPARTMENTALISATION OF LIPID SCAVENGING AND STORAGE
Lauren Thurgood, Lara Escane, Giles Best, Karen Lower, Bryone Kuss
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26 TARGETING TMEM176A ENHANCES VENETOCLAX-INDUCED APOPTOSIS THROUGH INFLAMMASOME ACTIVATION IN LEUKEMIC CELLS
Angimar Uriepero, Florencia Rammauro, Marcela Vilarino, Daniel Prieto, Sofia Russo, Mercedes Segovia, Maria Elena Marquez, Francine Bittencourt, Catalina Berca, Victoria Remedi, Gimena Dos Santos, Marcelo Hill, Pablo Oppezzo
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27 PTBP1 REGULATES ALTERNATIVE SPLICING OF APOPTOTIC PROTEIN: IMPLICATIONS IN CLL AND IBRUTINIB RESISTANCE
Hua-Yuan Zhu, Xinqi Zheng, Xiaotong Li, Jue-jin Wang, Hanning Tan, Li Wang, Wei Xu, Jian-Yong Li
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Abstract # CLINICAL POSTERS
28 BLOOD CELLULAR HAEMATOLOGICAL CHANGES IN PATIENTS WITH VISCERAL LEISHMANIASIS ATTENDING KIMALEL SUB-COUNTY HOSPITAL, BARINGO COUNTY
Lukas Agura
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29 ANTI-LEUKEMIC EFFECTS OF SYK INHIBITION IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) TREATED ON THE PHASE I/II STUDY OF ENTOSPLETINIB (ENTO) IN COMBINATION WITH OBINUTUZUMAB
Scott Best, Vi Lam, Adam Kittai, Alexey Danilov
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30 CHRONIC NEUTROPHILIC LEUKEMIA AFTER CHRONIC LYMPHOCYTIC LEUKEMIA
Maria Eduarda Couto, Susana Bizarro, Domingos Sousa, Nelson Domingues, Isabel Oliveira, Manuel Teixeira, José Mariz
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31 LONG-TERM EFFICACY AND SAFETY OF MAINTENANCE WITH LENALIDOMIDE IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKAEMIA AND A HIGH RISK OF PROGRESSION AFTER FIRST-LINE IMMUNOCHEMOTHERAPY
Anna Fink, Sandra Robrecht, Can Zhang, Moritz Fürstenau, Ali Aldaoud, Holger Hebart, Kathleen Jentsch-Ullrich, Steffen Doerfel, Kirsten Fischer, Clemens Wendtner, Thomas Noesslinger, Paolo Ghia, Francesc Bosch, Arnon Kater, Hartmut Döhner, Michael Kneba, Karl-Anton Kreuzer, Eugen Tausch, Stephan Stilgenbauer, Matthias Ritgen, Sebastian Böttcher, Barbara Eichhorst, Michael Hallek
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32 CLASSICAL PARAMETERS STILL PREDICT TREATMENT-FREE SURVIVAL IN THE ERA OF NOVEL THERAPIES:
ANALYSIS OF A CLL NATURAL HISTORY COHORT

Paul J. Hengeveld, Arnon P. Kater, Julie M. N. Dubois, Anton W. Langerak, Peter E. Westerweel, Mark-David Levin
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33 CLINICAL PRACTICE EXPERIENCE OF IBRUTINIB THERAPY IN CHRONIC LYMPHOCYTIC LEUKEMIA
Francisca Miranda, Ana Jorge, Celina Afonso
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34 GOOD RESPONSE TO FC-R IN PATIENT WITH LOW LEVEL DEL(17)P CLL CLONE
Cláudia Pedrosa, Rita Coutinho, Jorge Coutinho
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35 OVEREXPRESSION OF AID AND LPL RELATED TO CLL-IPI PROGNOSTIC INDEX AND ITS IMPACT ON TIME TO FIRST TREATMENT
Victoria Remedi, Ana Ines Landoni, Victoria Irigoin, Carolina Oliver, Cecilia Guillermo, Lilian Diaz, Daniel Prieto, Angimar Uriepero, Pablo Oppezzo, Raúl Gabús
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36 PHENOTYPIC CHANGES IN CLL CELLS IN A PATIENT ACQUIRING VENETOCLAX RESISTANCE
Ferenc Takács, Gábor Mikala, Dóra Aczél, Andrea Reszegi, Ágnes Czeti, Donát Alpár, Csaba Bödör, Gábor Szalóki, Ilona Kardos, Gábor Barna
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37 THE PROGNOSTIC SIGNIFICANCE OF DIFFERENT TYPES OF NEUTROPENIA IN CLL PATIENTS TREATED WITH FCR
Kristina Tomic, Vladislava Djurasinovic, Darko Antic, Vojin Vukovic, Vladimir Otasevic, Nada Kraguljac-Kurtovic, Jelica Jovanovic and Biljana Mihaljevic
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38 CAUSE OF DEATH IN PATIENTS WITH NEWLY DIAGNOSED CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) STRATIFIED BY THE CLL-INTERNATIONAL PROGNOSTIC INDEX (CLL-IPI)
Yucai Wang, Sara Achenbach, Kari Rabe, Tait Shanafelt, Timothy Call, Wei Ding, Saad Kenderian, Eli Muchtar, Jose Leis, Amber Koehler, Susan Schwager, James Cerhan, Susan Slager, Neil Kay and Sameer Parikh
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SELECTED ABSTRACTS FOR POSTER PRESENTATIONS IN ALPHABETIC ORDER ACCORDING TO THE NAME OF THE FIRST AUTHOR